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They often reflect: Slowed digestion Impaired bile flow Under-fueling Nervous system stress Instead of investigating the cause, patients are frequently told their body will adjust. Sometimes it does

In the periphery, posttranslational processing of preproglucagon in the alpha-cells of the pancreas produces glucagon and a small amount of GLP-1 whereas the main source of peripheral GLP-1 production occurs through the posttranslational processing of preproglucagon in the L-cells of the gut (reviewed in Holst, 1992

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Interestingly, the liver, which is part of lean body mass, represents a larger proportion of total body weight in females